{"id":2741,"date":"2025-08-14T22:01:00","date_gmt":"2025-08-14T14:01:00","guid":{"rendered":"\/\/m.relmradio.com\/?p=2741"},"modified":"2025-08-15T13:44:49","modified_gmt":"2025-08-15T05:44:49","slug":"%e8%b6%8a%e6%9d%a5%e8%b6%8a%e5%a4%9a%e5%b9%b4%e8%bd%bb%e4%ba%ba%e6%82%a3%e4%b8%8a%e8%bf%99%e7%a7%8d%e7%99%8c%e7%97%87%ef%bc%8c%e6%a0%b9%e6%ba%90%e5%8f%af%e8%83%bd%e5%9c%a8%e7%ab%a5%e5%b9%b4","status":"publish","type":"post","link":"\/\/m.relmradio.com\/?p=2741","title":{"rendered":"\u8d8a\u6765\u8d8a\u591a\u5e74\u8f7b\u4eba\u60a3\u4e0a\u8fd9\u79cd\u764c\u75c7\uff0c\u6839\u6e90\u53ef\u80fd\u5728\u7ae5\u5e74"},"content":{"rendered":"
\n
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\u56fe\u7247\u6765\u6e90\uff1aunsplash<\/a><\/span><\/figcaption><\/figure><\/div>\n\n\n
\u4e00\u79cd\u7ec6\u83cc\u6bd2\u7d20\u53ef\u80fd\u662f\u5143\u51f6\u3002<\/section>\n\n\n\n
\u64b0\u6587 | \u9ec4\u96e8\u4f73
\u5ba1\u6821 | clefable

<\/strong>\n\n\n\n

\u8bb0\u5f97\u6211\u4e0a\u5927\u5b66\u519b\u8bad\u65f6\uff0c\u6559\u5b98\u66fe\u5728\u5927\u5587\u53ed\u91cc\u8bb2\u8fc7\u4e00\u4e2a\u771f\u5b9e\u6848\u4f8b\uff1a\u4e00\u540d\u4e60\u60ef\u6027\u4fbf\u79d8\u7684\u540c\u5b66\uff0c\u7a81\u7136\u5f00\u59cb\u9891\u7e41\u8179\u6cfb\u3002\u4ed6\u8d77\u521d\u6ca1\u5f53\u56de\u4e8b\uff0c\u76f4\u5230\u75c7\u72b6\u4e25\u91cd\u624d\u53bb\u5c31\u533b\uff0c\u7ed3\u679c\u5df2\u662f\u7ed3\u76f4\u80a0\u764c\u665a\u671f\uff0c\u4e0d\u4e45\u4fbf\u79bb\u5f00\u4e86\u4eba\u4e16\u3002\u5c3d\u7ba1\u8fd9\u4e2a\u6545\u4e8b\u6df1\u6df1\u5370\u523b\u5728\u6211\u7684\u8111\u6d77\u91cc\uff0c\u53ef\u6211\u59cb\u7ec8\u89c9\u5f97\u7ed3\u76f4\u80a0\u764c\u662f\u79cd\u201c\u8001\u5e74\u75c5\u201d\u3002\u76f4\u5230\u524d\u4e9b\u5e74\uff0c\u5bb6\u91cc\u4e00\u4f4d\u548c\u6211\u5e74\u7eaa\u76f8\u4eff\u7684\u4eb2\u621a\u4e5f\u56e0\u7ed3\u76f4\u80a0\u764c\u53bb\u4e16\uff0c\u6211\u624d\u610f\u8bc6\u5230\uff0c\u5f97\u7ed3\u76f4\u80a0\u764c\u7684\u5e74\u8f7b\u4eba\u5e76\u4e0d\u7f55\u89c1\uff0c\u751a\u81f3\u4f3c\u4e4e\u8d8a\u6765\u8d8a\u591a\u4e86\u3002<\/p>\n\n\n\n

\u8fd9\u5e76\u4e0d\u662f\u6211\u7684\u9519\u89c9\u3002\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u5168\u7403\u764c\u75c7\u89c2\u5bdf\u7ad9\uff08Global Cancer Observatory\uff09\u63d0\u4f9b\u7684\u6570\u636e<\/a>\uff0c2002-2017\u5e74\uff0c\u6211\u56fd25\uff5e29\u5c81\u4eba\u7fa4\u7684\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u5728\u77ed\u77ed15\u5e74\u95f4\u7ffb\u4e86\u4e00\u756a<\/strong>\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c80\uff5e84\u5c81\u8001\u5e74\u4eba\u7684\u53d1\u75c5\u7387\u867d\u4ecd\u7136\u5f88\u9ad8\uff0c\u4f46\u53d8\u5316\u4e0d\u5927\u3002\u66f4\u4ee4\u4eba\u62c5\u5fe7\u7684\u662f\uff0c\u8fd9\u79cd\u8d8b\u52bf\u5e76\u975e\u53ea\u5728\u4e2d\u56fd\u51fa\u73b0\u3002\u8fc7\u53bb20\u5e74\uff0c\u5168\u740350\u5c81\u4ee5\u4e0b\u4eba\u7fa4\u7684\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u663e\u8457\u4e0a\u5347\uff0c\u5927\u7ea6\u6bcf\u5341\u5e74\u7ffb\u4e00\u756a\u3002\u7167\u6b64\u4e0b\u53bb\uff0c\u52302030\u5e74\uff0c\u7ed3\u76f4\u80a0\u764c\u5c06\u6210\u4e3a\u9752\u58ee\u5e74\u764c\u75c7\u6b7b\u4ea1\u7684\u9996\u8981\u539f\u56e0\u3002<\/strong><\/p>\n\n\n

\n
\"\"
\u6570\u636e\u663e\u793a\uff0c2002-2017\u5e74\uff0c\u6211\u56fd25\uff5e29\u5c81\u4eba\u7fa4\u7684\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u7ffb\u4e86\u4e00\u756a\uff08\u56fe\u7247\u6765\u6e90\uff1a\u5168\u7403\u764c\u75c7\u89c2\u5bdf\u7ad9<\/a>\uff09<\/span><\/figcaption><\/figure><\/div>\n\n\n

\u4ee4\u4eba\u4e0d\u89e3\u7684\u662f\uff0c\u8fd9\u4e9b\u65e9\u53d1\u60a3\u8005\u5f80\u5f80\u6ca1\u6709\u5bb6\u65cf\u75c5\u53f2\uff0c\u4e5f\u5f88\u5c11\u6709\u80a5\u80d6\u3001\u9ad8\u8840\u538b\u7b49\u4f20\u7edf\u98ce\u9669\u56e0\u7d20<\/strong>\u3002\u79d1\u5b66\u5bb6\u6000\u7591\uff0c\u5f88\u53ef\u80fd\u662f\u67d0\u79cd\u73af\u5883\u56e0\u7d20\u5728\u80cc\u540e\u4f5c\u795f\u3002\u5728\u4e00\u7bc7\u4eca\u5e744\u6708\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b<\/a>\uff08Nature<\/em>\uff09\u7684\u8bba\u6587\u4e2d\uff0c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\uff08UCSD\uff09\u7684\u7814\u7a76\u4eba\u5458\u4e3a\u6211\u4eec\u63ed\u793a\u4e86\u4e00\u79cd\u65b0\u7684\u53ef\u80fd\uff1a\u5728\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u6fc0\u589e\u7684\u80cc\u540e\uff0c\u6216\u8bb8\u4e0e\u4eba\u4eec\u7ae5\u5e74\u65f6\u671f\u63a5\u89e6\u8fc7\u4e00\u79cd\u540d\u4e3acolibactin\u7684\u7ec6\u83cc\u6bd2\u7d20\u6709\u5173<\/strong>\u3002<\/p>\n\n\n\n



\u80cc\u540e\u5143\u51f6<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

\u8981\u627e\u5230\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u81f4\u764c\u56e0\u7d20\u5e76\u4e0d\u5bb9\u6613\u3002\u4e0d\u8fc7\uff0c\u8bb8\u591a\u81f4\u764c\u56e0\u7d20\u4f1a\u5728DNA\u4e0a\u7559\u4e0b\u201c\u6307\u7eb9\u201d\u3002\u5b83\u4eec\u4e0d\u4ec5\u4f1a\u5e26\u6765\u57fa\u56e0\u7a81\u53d8\uff0c\u8fd8\u4f1a\u5f62\u6210\u7279\u6709\u7684\u7a81\u53d8\u6a21\u5f0f<\/strong>\u3002\u4e8e\u662f\uff0c\u7814\u7a76\u4eba\u5458\u51b3\u5b9a\u4ece\u764c\u75c7\u7ec4\u7ec7\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u5165\u624b\u5bfb\u627e\u7ebf\u7d22\uff0c\u5206\u6790\u4e86\u6765\u81ea4\u5927\u6d3211\u4e2a\u56fd\u5bb6\u7684981\u4efd\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u80bf\u7624\u6837\u672c\u3002<\/p>\n\n\n\n

\u4ed6\u4eec\u53d1\u73b0\uff0c\u5728\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u6837\u672c\u4e2d\uff0c\u6709\u4e24\u79cdDNA\u7a81\u53d8\u6a21\u5f0f<\/strong>\uff08SBS88\u548cID18\uff09\u7684\u51fa\u73b0\u9891\u7387\u663e\u8457\u9ad8\u4e8e\u8001\u5e74\u53d1\u75c5\u60a3\u8005\u3002\u5177\u4f53\u800c\u8a00\uff0c\u572850\u5c81\u524d\u786e\u8bca\u7684\u60a3\u8005\u4f53\u5185\uff0cSBS88\u51fa\u73b0\u7684\u9891\u7387\u662f50\u5c81\u540e\u786e\u8bca\u60a3\u8005\u76842.5\u500d\uff0cID18\u7684\u51fa\u73b0\u9891\u7387\u66f4\u662f\u9ad8\u8fbe4\u500d\u3002\u540c\u65f6\uff0c\u8fd9\u4e9b\u7a81\u53d8\u6a21\u5f0f\u5728\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u9ad8\u53d1\u7684\u56fd\u5bb6\u5c24\u4e3a\u666e\u904d\uff0c\u8fd8\u4e0e\u5927\u91cf\u80fd\u63a8\u52a8\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u7684\u5173\u952e\u57fa\u56e0\u7a81\u53d8\u6709\u5173\u3002<\/p>\n\n\n\n

\u6b64\u524d\u7684\u7814\u7a76\u65e9\u5df2\u8bc1\u5b9e\uff0c\u8fd9\u4e24\u79cd\u7a81\u53d8\u6a21\u5f0f\u4e0e\u4e00\u79cd\u540d\u4e3acolibactin\u7684\u7ec6\u83cc\u6bd2\u7d20\u5bc6\u5207\u76f8<\/strong>\u5173<\/strong>\u3002Colibactin\u662f\u4e00\u79cd\u57fa\u56e0\u6bd2\u7d20\uff0c\u7531\u5927\u80a0\u6746\u83cc\u7b49\u7ec6\u83cc\u4ea7\u751f\u3002\u5f53\u5b83\u4eec\u4e0e\u7ade\u4e89\u7684\u7ec6\u83cc\u53d1\u751f\u201c\u6218\u4e89\u201d\u65f6\uff0c\u5c31\u4f1a\u7528\u8fd9\u79cd\u5316\u5408\u7269\u6765\u7834\u574f\u5bf9\u65b9\u7684DNA\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u4eba\u4f53\u7ec6\u80de\u66b4\u9732\u4e8ecolibactin\u540e\uff0c\u540c\u6837\u4e5f\u4f1a\u51fa\u73b0DNA\u53cc\u94fe\u65ad\u88c2\u548c\u67d3\u8272\u4f53\u7578\u53d8\u3002\u5927\u7ea610%\uff5e15%\u7684\u7ed3\u76f4\u80a0\u764c\u75c5\u4f8b\u4f53\u5185\u90fd\u5b58\u5728\u4e0ecolibactin\u76f8\u5173\u7684\u7a81\u53d8\uff0c\u79d1\u5b66\u5bb6\u4e5f\u65e9\u5df2\u5c06\u8fd9\u79cd\u6bd2\u7d20\u5217\u4e3a\u7ed3\u76f4\u80a0\u764c\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u53ea\u662f\u4e00\u76f4\u6ca1\u6709\u5c06\u5b83\u4e0e\u7ed3\u76f4\u80a0\u764c\u7684\u65e9\u53d1\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n\n\n

\n
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colibactin\u7684\u7ed3\u6784\uff08\u56fe\u7247\u6765\u6e90\uff1aInnerstream<\/a>, Public domain, via Wikimedia Commons\uff09<\/span><\/figcaption><\/figure><\/div>\n\n\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5e76\u975e\u6240\u6709\u5927\u80a0\u6746\u83cc\u90fd\u80fd\u5236\u9020colibactin\uff0c\u53ea\u6709\u57fa\u56e0\u7ec4\u4e2d\u643a\u5e26pks\u6bd2\u529b\u5c9b\u7684\u83cc\u682a\u624d\u5177\u5907\u8fd9\u4e00\u80fd\u529b\uff08\u5176\u4ed6\u7ec6\u83cc\u4e5f\u9700\u8981pks\u6bd2\u529b\u5c9b\u624d\u80fd\u4ea7\u751fcolibactin\uff09\u3002\u4f46\u5947\u602a\u7684\u662f\uff0c\u7814\u7a76\u4eba\u5458\u5728\u5f88\u591a\u62e5\u6709SBS88\u548cID18\u7a81\u53d8\u7684\u60a3\u8005\u4f53\u5185\uff0c\u5e76\u6ca1\u6709\u76f4\u63a5\u68c0\u6d4b\u5230\u62e5\u6709pks\u6bd2\u529b\u5c9b\u7684\u7ec6\u83cc\uff0c\u4e24\u8005\u4f3c\u4e4e\u53c8\u6ca1\u4e86\u5173\u8054\u3002\u4e0d\u8fc7\uff0c\u8fd9\u4e9b\u7a81\u53d8\u6a21\u5f0f\u4f1a\u5728\u57fa\u56e0\u7ec4\u4e0a\u7559\u4e0b\u201c\u5386\u53f2\u8bb0\u5f55\u201d\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5206\u6790\u5b83\u4eec\u5728\u57fa\u56e0\u7ec4\u4e0a\u51fa\u73b0\u7684\u65f6\u95f4\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7a81\u53d8\u5f80\u5f80\u51fa\u73b0\u5728\u764c\u75c7\u53d1\u751f\u7684\u65e9\u671f\u9636\u6bb5<\/strong>\u3002<\/p>\n\n\n\n

\u8fd9\u7bc7\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u5362\u5fb7\u7c73\u5c14\u00b7\u4e9a\u5386\u5c71\u5fb7\u7f57\u592b\uff08Ludmil Alexandrov\uff09\u63a8\u6d4b\uff0c\u60a3\u8005\u63a5\u89e6\u8fd9\u4e9b\u4ea7colibactin\u7ec6\u83cc\u7684\u65f6\u95f4\uff0c\u53ef\u80fd\u662f\u5728\u786e\u8bca\u7ed3\u76f4\u80a0\u764c\u7684\u6570\u5341\u5e74\u524d\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u8fd9\u4e9b\u60a3\u8005\u5f88\u53ef\u80fd\u5728\u513f\u7ae5\u65f6\u671f\uff08\u4f8b\u598210\u5c81\u524d\uff09\u5c31\u63a5\u89e6\u8fc7\u4ea7colibactin\u7684\u7ec6\u83cc<\/strong>\uff0c\u4ed6\u4eec\u7684\u7ed3\u76f4\u80a0\u4e0a\u76ae\u7ec6\u80de\u56e0\u6b64\u51fa\u73b0\u4e86\u5927\u91cfDNA\u635f\u4f24\uff0c\u76f8\u5f53\u4e8e\u63d0\u524d\u79ef\u7d2f\u4e86\u666e\u901a\u4eba\u9700\u8981\u51e0\u5341\u5e74\u65f6\u95f4\u624d\u80fd\u79ef\u7d2f\u7684\u7a81\u53d8\u3002<\/p>\n\n\n\n

\u968f\u7740\u80a0\u9053\u83cc\u7fa4\u7684\u81ea\u7136\u66f4\u66ff\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u5df2\u7ecf\u6162\u6162\u88ab\u5176\u4ed6\u5fae\u751f\u7269\u53d6\u4ee3\uff0c\u53ef\u5b83\u4eec\u5728\u4eba\u80a0\u9053\u7ec6\u80de\u57fa\u56e0\u7ec4\u4e0a\u7559\u4e0b\u7684\u4f24\u75d5\u6210\u4e86\u4e00\u9897\u201c\u5b9a\u65f6\u70b8\u5f39\u201d\u3002\u4e8e\u662f\u672c\u8be5\u5728\u8001\u5e74\u624d\u9ad8\u53d1\u7684\u7ed3\u76f4\u80a0\u764c\uff0c\u624d\u4f1a\u63d0\u65e9\u5728\u5e74\u8f7b\u4eba\u8eab\u4e0a\u51fa\u73b0\u3002\u4e9a\u5386\u5c71\u5fb7\u7f57\u592b\u8bf4\uff1a\u201c\u5982\u679c\u4e00\u4e2a\u4eba\u572810\u5c81\u524d\u5c31\u6709\u4e86\u8fd9\u4e9b\u7a81\u53d8\uff0c\u90a3\u4e48\u4ed6\u4eec\u60a3\u4e0a\u7ed3\u76f4\u80a0\u764c\u7684\u65f6\u95f4\u7ebf\u53ef\u80fd\u4f1a\u63d0\u65e9\u6570\u5341\u5e74\u3002\u539f\u672c\u8981\u523060\u5c81\u624d\u53d1\u75c5\u7684\u4eba\uff0c\u53ef\u80fd40\u5c81\u65f6\u5c31\u60a3\u75c5\u4e86\u3002\u201d<\/p>\n\n\n\n



\u591a\u79cd\u56e0\u7d20<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

\u4e0d\u8fc7\uff0c\u4ea7colibactin\u7684\u7ec6\u83cc\u5e76\u975e\u552f\u4e00\u4e0e\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u7684\u5fae\u751f\u7269<\/strong>\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u56e2\u961f\u8fd8\u53d1\u73b0\u4e86\u4e00\u79cd\u540d\u4e3aSBS89\u7684\u57fa\u56e0\u7a81\u53d8\u3002\u5b83\u4e0eSBS88\u548cID18\u5728\u8bb8\u591a\u65b9\u9762\u90fd\u975e\u5e38\u76f8\u4f3c\uff0c\u5f88\u6709\u53ef\u80fd\u4e5f\u4e0e\u67d0\u79cd\u80a0\u9053\u7ec6\u83cc\u6709\u5173\uff0c\u800c\u4e14\u5f88\u53ef\u80fd\u4e5f\u51fa\u73b0\u5728\u60a3\u8005\u7684\u751f\u547d\u65e9\u671f\u3002\u6b64\u5916\uff0c\u8fc7\u53bb\u7684\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u4e00\u79cd\u540d\u4e3a\u5177\u6838\u68ad\u6746\u83cc\uff08Fusobacterium nucleatum<\/em>\uff09\u7684\u7ec6\u83cc\uff0c\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u65b9\u5f0f\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u5e76\u9003\u907f\u514d\u75ab\u7cfb\u7edf\uff0c\u6765\u63a8\u52a8\u7ed3\u76f4\u80a0\u764c\u7684\u53d1\u5c55\u3002<\/p>\n\n\n

\n
\"\"
\u5177\u6838\u68ad\u6746\u83cc\uff08\u56fe\u7247\u6765\u6e90\uff1aDr. V. R. Dowell, Public domain, via Wikimedia Commons\uff09<\/span><\/figcaption><\/figure><\/div>\n\n\n

\u81f3\u4e8e\u5b69\u5b50\u4eec\u7a76\u7adf\u5982\u4f55\u63a5\u89e6\u5230\u4e86\u8fd9\u4e9b\u4ea7colibactin\u7684\u7ec6\u83cc\uff0c\u79d1\u5b66\u5bb6\u76ee\u524d\u4ecd\u4e0d\u6e05\u695a\u3002\u800c\u4e14\uff0c\u5927\u7ea6\u670920%\uff5e30%\u7684\u4eba\u4f53\u5185\u90fd\u643a\u5e26\u6709pks\u6bd2\u529b\u5c9b\u7684\u7ec6\u83cc\u3002\u5b83\u4eec\u5e76\u975e\u8fd1\u51e0\u5341\u5e74\u624d\u51fa\u73b0\uff0c\u53ef\u7ed3\u76f4\u80a0\u764c\u7684\u6fc0\u589e\u5374\u662f\u5728\u8fd1\u51e0\u5341\u5e74\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u63a8\u6d4b\uff0c\u6297\u751f\u7d20\u7684\u4f7f\u7528\u548c\u996e\u98df\u4e60\u60ef\u7684\u53d8\u5316\u7b49\u53ef\u80fd\u8d77\u5230\u4e86\u63a8\u6ce2\u52a9\u6f9c\u7684\u4f5c\u7528<\/strong>\u3002\u4f8b\u5982\uff0c\u4e00\u98792025\u5e743\u6708\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u00b7\u5fae\u751f\u7269\u5b66\u300b<\/a>\uff08Nature Microbiology<\/em>\uff09\u7684\u7814\u7a76\u5c31\u8868\u660e\uff0c\u996e\u98df\u4e2d\u7684\u81b3\u98df\u7ea4\u7ef4\u5176\u5b9e\u53ef\u4ee5\u6291\u5236\u4ea7colibactin\u7684\u5927\u80a0\u6746\u83cc\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u81f4\u764c\u6f5c\u529b\u3002<\/p>\n\n\n\n

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\u4e0d\u8fc7\uff0c\u4e9a\u5386\u5c71\u5fb7\u7f57\u592b\u540c\u65f6\u5f3a\u8c03\uff0c\u8fd9\u9879\u7814\u7a76\u53ea\u662f\u53d1\u73b0\u4e86\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u4e0ecolibactin\u76f8\u5173\u7a81\u53d8\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u4e3a\u201c\u7ae5\u5e74\u63a5\u89e6colibactin\u53ef\u80fd\u4e0e\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u6709\u5173\u201d\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u652f\u6301\u3002\u4f46\u8981\u786e\u5b9a\u4e8c\u8005\u4e4b\u95f4\u660e\u786e\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u8fd8\u9700\u8981\u66f4\u6df1\u5165\u7684\u7814\u7a76\u3002<\/strong>\u5982\u679c\u8fd9\u79cd\u56e0\u679c\u5173\u7cfb\u6700\u7ec8\u88ab\u8bc1\u5b9e\uff0c\u90a3\u4e48\u65e9\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u6fc0\u589e\u7684\u73b0\u8c61\uff0c\u5f88\u53ef\u80fd\u4e0e\u4ea7colibactin\u7ec6\u83cc\u5728\u4eba\u7fa4\u4e2d\u53d8\u5f97\u6d41\u884c\u6709\u5173\u3002<\/p>\n\n\n\n

\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u89c6\u89d2\u3002\u4e0d\u4ec5\u662f\u7ed3\u76f4\u80a0\u764c\uff0c\u5176\u4ed6\u764c\u75c7\u4e5f\u53ef\u80fd\u5b58\u5728\u7c7b\u4f3c\u7684\u673a\u5236\uff1a\u5f88\u53ef\u80fd\u6211\u4eec\u7ae5\u5e74\u65f6\u671f\u63a5\u89e6\u8fc7\u7684\u67d0\u79cd\u73af\u5883\u6216\u5fae\u751f\u7269\u56e0\u7d20\uff0c\u5df2\u7ecf\u6084\u65e0\u58f0\u606f\u5730\u57cb\u4e0b\u4e86\u75be\u75c5\u7684\u79cd\u5b50<\/strong>\u3002\u4f8b\u5982\uff0c\u4e00\u98792025\u5e745\u6708\u53d1\u8868\u4e8e\u300a\u67f3\u53f6\u5200\u00b7\u5fae\u751f\u7269\u300b<\/a>\uff08The Lancet Microbe<\/em>\uff09\u7684\u7814\u7a76\u5c31\u53d1\u73b0\uff0c\u8180\u80f1\u764c\u3001\u524d\u5217\u817a\u764c\u7b49\u540c\u6837\u4e0e\u4ea7colibactin\u7ec6\u83cc\u9ad8\u5ea6\u76f8\u5173\u3002<\/p>\n\n\n\n

\u56e0\u6b64\uff0c\u764c\u75c7\u9884\u9632\u7684\u7a97\u53e3\u4e5f\u8bb8\u6bd4\u6211\u4eec\u60f3\u8c61\u7684\u8981\u65e9\u5f97\u591a<\/strong>\u3002\u5982\u679c\u6211\u4eec\u80fd\u6df1\u5165\u7406\u89e3\u8fd9\u4e9b\u201c\u7ae5\u5e74\u5b9a\u65f6\u70b8\u5f39\u201d\u7684\u5f62\u6210\u673a\u5236\uff0c\u5e76\u91c7\u53d6\u6709\u6548\u63aa\u65bd\u907f\u514d\u513f\u7ae5\u65f6\u671f\u63a5\u89e6\u6709\u5bb3\u7684\u73af\u5883\u56e0\u7d20\uff0c\u6216\u8005\u901a\u8fc7\u7279\u5b9a\u65b9\u6cd5\u964d\u4f4e\u5176\u5371\u5bb3\uff0c\u90a3\u4e48\u6211\u4eec\u5c31\u6709\u53ef\u80fd\u5927\u5e45\u964d\u4f4e\u591a\u79cd\u65e9\u53d1\u6027\u764c\u75c7\u7684\u53d1\u75c5\u7387\uff0c\u5728\u764c\u75c7\u5c1a\u672a\u840c\u82bd\u65f6\u5207\u65ad\u5176\u6839\u6e90\u3002<\/p>\n\n\n\n
\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/gco.iarc.fr\/overtime\/en\/dataviz\/age_specific
https:\/\/www.nature.com\/articles\/s41586-025-09025-8
https:\/\/www.nature.com\/articles\/s41564-025-01938-4
https:\/\/www.thelancet.com\/journals\/lanmic\/article\/PIIS2666-5247(24)00283-0\/fulltext
https:\/\/today.ucsd.edu\/story\/childhood-exposure-to-bacterial-toxin-may-be-triggering-colorectal-cancer-epidemic-among-the-young
https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/04\/25\/g-s1-62623\/colon-cancer-gut-health-microbiome-young
<\/strong>\n","protected":false},"excerpt":{"rendered":"

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