{"id":1680,"date":"2024-07-13T22:01:00","date_gmt":"2024-07-13T14:01:00","guid":{"rendered":"\/\/m.relmradio.com\/?p=1680"},"modified":"2024-12-05T16:49:14","modified_gmt":"2024-12-05T08:49:14","slug":"%e4%bd%8e%e8%b0%83%e5%8f%88%e8%bf%b7%e4%ba%ba%ef%bc%8c%e5%ae%83%e5%ae%8c%e6%88%90%e4%ba%86dna%e5%92%8c%e8%9b%8b%e7%99%bd%e8%b4%a8%e9%83%bd%e6%97%a0%e6%b3%95%e5%81%9a%e5%88%b0%e7%9a%84%e4%ba%8b","status":"publish","type":"post","link":"\/\/m.relmradio.com\/?p=1680","title":{"rendered":"\u4f4e\u8c03\u53c8\u8ff7\u4eba\uff0c\u5b83\u5b8c\u6210\u4e86DNA\u548c\u86cb\u767d\u8d28\u90fd\u65e0\u6cd5\u505a\u5230\u7684\u4e8b | \u897f\u6e56\u5927\u5b66\u4ed8\u5411\u4e1c\u6559\u6388\u5bf9\u8c08\u300a\u73af\u7403\u79d1\u5b66\u300b"},"content":{"rendered":"\n<section data-autoskip=\"1\" style=\"overflow: auto; line-height: 2.45; padding: 20px; border-radius: 5px; overflow-wrap: normal; color: rgb(1, 1, 1); background-color: rgb(213, 220, 225);\"><span style=\"letter-spacing: 1px; font-size: 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class=\"wp-block-audio\"><audio controls src=\"\/\/m.relmradio.com\/wp-content\/uploads\/2024\/12\/\u975e\u7f16\u7801RNA-v2.mp3\"><\/audio><\/figure>\n\n\n\n<strong style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px; line-height: 200%;\"><br>\u672c\u520a\u8bb0\u8005 | 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sarcoma virus\uff09\u3002\u8fd9\u662f\u4e00\u79cdRNA\u75c5\u6bd2\uff0c\u6211\u90a3\u65f6\u5019\u7814\u7a76\u5b83\u7684\u590d\u5236\u3002\u56e0\u4e3a\u5b83\u7684\u57fa\u56e0\u7ec4\u662fRNA\u561b\uff0c\u6211\u4eec\u7814\u7a76\u8fd9\u4e2aRNA\u75c5\u6bd2\u7684\u88c5\u914d\u7684\u673a\u7406\u3002<\/p>\n\n\n\n<p>\u5b9e\u9645\u4e0a<strong>RNA\u4e00\u76f4\u633a\u706b\u70ed\u7684\uff0c\u4e00\u76f4\u662f\u53d1\u73b0\u7684\u4e2d\u5fc3\uff0c\u6bcf\u9694\u51e0\u5e74\u5c31\u6709\u4e00\u4e2a\u7a81\u7834<\/strong>\u3002\u6211\u505a\u535a\u58eb\u540e\u65f6\u5019\u7684\u7a81\u7834\u5c31\u662f\u505a\u5230\u4e86\u4f53\u5916\u526a\u63a5\uff08in vitro 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University\uff09\u3002\u4ed6\u4eec\u5b9e\u9a8c\u5ba4\uff08lab\uff09\u4e5f\u662f\u4e00\u76f4\u5f88\u524d\u6cbf\uff0c\u505aRNA\u52a0\u5de5\u7684\u76f8\u5173\u7814\u7a76\u3002\u540c\u65f6\u90a3\u4e2a\u5b9e\u9a8c\u5ba4\u4e0d\u5149\u505a\u526a\u63a5\uff08splicing\uff09\uff0c\u4e5f\u505a\u8f6c\u5f55\uff08transcription\uff09\uff0c\u6240\u4ee5\u6211\u89c9\u5f97\u633a\u9002\u5408\u6211\u7684\u3002\u5b9e\u9645\u4e0a\u6211\u5c31\u7533\u8bf7\u4e86\u90a3\u4e48\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\uff08lab\uff09\u505a\u535a\u58eb\u540e\uff0c\u7136\u540e\u4ed6\u5c31\u5f55\u53d6\u6211\u4e86\u3002<\/p>\n\n\n\n<p>\u6211\u5728\u4ed6\u7684\u5b9e\u9a8c\u5ba4\uff08lab\uff09\u505a\u4e86\u5f88\u591a\u6709\u610f\u601d\u7684\u4e8b\u60c5\uff0c\u5305\u62ec\u9274\u5b9a\u4e86\u7b2c\u4e00\u4e2a\u526a\u63a5\u4f53\u7684\u56e0\u5b50\uff0c\u540e\u6765\u5bfc\u81f4\u4e86SR\u86cb\u767d\u5bb6\u65cf\u7684\u53d1\u73b0\uff0c\u8fd9\u4e2a\u86cb\u767d\u5bb6\u65cf\u53c2\u4e0e\uff08involve\uff09\u4e86\u7ec4\u6210\u578b\u526a\u63a5\uff08constitutive splicing\uff09\u548c\u9009\u62e9\u578b\u526a\u63a5\uff08regulatory splicing\uff09\u7684RNA\u52a0\u5de5\u3002\u540e\u6765\u8fd9\u4e2a\u5de5\u4f5c\u505a\u5b8c\u4e86\u4ee5\u540e\uff0c\u6211\u5c31\u5f88\u987a\u5229\u5730\u627e\u5230\u4e86\u5de5\u4f5c\u3002\u6240\u4ee5\u4ece1992\u5e74\u5f00\u59cb\uff0c\u6211\u5c31\u52a0\u5165\u4e86\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\uff08UC San Diego\uff09\uff0c\u7ee7\u7eed\u505aRNA\u7684\u7814\u7a76\uff0c\u4e00\u76f4\u5230\u4eca\u5929\uff0c\u7b97\u8d77\u6765\u73b0\u5728\u4e5f\u670940\u5e74\u7684\u8015\u8018\u4e86\u3002\u6240\u4ee5\u6211\u5bf9RNA\u7684\u52a0\u5de5\uff0c\u4e0d\u7ba1\u662f\u7f16\u7801\uff08coding\uff09RNA\u8fd8\u662f\u975e\u7f16\u7801\uff08noncoding\uff09RNA\uff0c\u4ee5\u53caRNA\u529f\u80fd\u6709\u4e00\u7cfb\u5217\u7684\u7814\u7a76\u3002<\/p>\n\n\n\n<p>\u56de\u60f3\u8d77\u6765\uff0c\u5927\u6982\u6211\u4e3b\u8981\u7684\u5de5\u4f5c\u5173\u6ce8\uff08focus\uff09\u5728\uff1a\u7b2c\u4e00\u9636\u6bb5\u7684\u8bdd\u4e3b\u8981\u662f\u770b\u526a\u63a5\u4f53\u3001\u4e00\u4e9b\u8c03\u63a7\u86cb\u767d\u600e\u4e48\u6765\u8c03\u63a7RNA\u7684\u52a0\u5de5\uff1b\u56e0\u4e3a\u8fd9\u4e2a\u91cc\u5934\u5c31\u6709\u5f88\u591aRNA\u7ed3\u5408\u86cb\u767d\uff0c\u4e8e\u662f\u5c31\u6269\u5c55\uff08expand\uff09\u5230RNA\u7ed3\u5408\u86cb\u767d\u53bb\u4e86\u3002\u540e\u6765\u6211\u4eec\u5c31\u53d1\u73b0<strong>RNA\u7ed3\u5408\u86cb\u767d\u6709\u5f88\u591a\u5f88\u591a\u4e0d\u540c\u7684\u529f\u80fd\uff0c\u4e0d\u5149\u662f\u5728RNA\u7684\u52a0\u5de5\u65b9\u9762\uff0c\u5b9e\u9645\u4e0a\u5728\u8f6c\u5f55\u91cc\u4e5f\u6709\u5f88\u591a\u4f5c\u7528\uff0c\u5f53\u7136\u8fd8\u6709\u4e4b\u540e\u7684\u7ffb\u8bd1\u4ec0\u4e48\u7684<\/strong>\u3002\u6240\u4ee5\u975e\u7f16\u7801\uff08noncoding\uff09RNA\u4e5f\u63a5\u89e6\u4e86\u5f88\u591a\u3002<\/p>\n\n\n\n<p>\u5b9e\u9645\u4e0a\uff0c\u540e\u6765\u6211\u4eec\u8fd8\u53d1\u73b0\uff0c<strong>\u975e\u7f16\u7801<\/strong>\uff08noncoding\uff09<strong>RNA\u548c\u7f16\u7801<\/strong>\uff08coding\uff09<strong>RNA\u5b9e\u9645\u4e0a\u4e5f\u6ca1\u6709\u90a3\u4e48\u5f3a\u7684\u754c\u5b9a<\/strong>\u3002\u7f16\u7801\uff08coding\uff09RNA\u5728\u771f\u6b63\u4f5c\u4e3a\u4fe1\u4f7fRNA\uff08mRNA\uff09\u4e4b\u524d\uff0c\u5728\u5b83\u52a0\u5de5\u7684\u65f6\u5019\u6216\u8005\u8f6c\u5f55\uff08transcription\uff09\u7684\u65f6\u5019\uff0c\u5b83\u672c\u6765\u5c31\u662f\u4f5c\u4e3a\u975e\u7f16\u7801RNA\u8d77\u4f5c\u7528\uff08function as noncoding RNA\uff09\u7684\uff0c\u5728\u7ec6\u80de\u6838\u91cc\u9762\u3002\u56e0\u4e3a\u5728\u7ec6\u80de\u6838\u91cc\u5b83\u4e5f\u4e0d\u7f16\u7801\uff0c\u6240\u4ee5\u90a3\u4e2a\u65f6\u5019\u5b83\u4eec\u81ea\u5df1\u8981\u8d77\u5f88\u591a\u7684\u4f5c\u7528\u3002\u5f53\u65f6\u6211\u4eec\u5c31\u5f3a\u8c03\uff0c\u5b9e\u9645\u4e0a\u662f\u5728RNA\u52a0\u5de5\u6210\u719f\u3001\u771f\u6b63\u884c\u4f7f\u4fe1\u4f7fRNA\uff08mRNA\uff09\u529f\u80fd\u4e4b\u524d\uff0c\u5b9e\u9645\u4e0a\u8d77\u4f5c\u7528\uff08function\uff09\u7684\u5c31\u662f\u975e\u7f16\u7801\uff08noncoding\uff09RNA\u3002<\/p>\n\n\n\n<p>\u90a3\u5f53\u7136\u4e0d\u662f\u8bf4\u6240\u6709\u7684\u90fd\u6709\u529f\u80fd\u4e86\u3002\u8fd9\u91cc\u7275\u6d89\u5230\u8f6c\u5f55\u52a0\u5de5\u548c\u8f6c\u8fd0\u7684\u8fc7\u7a0b\u91cc\uff0c\u53c2\u4e0e\u4e86\u4e00\u4e9b\u57fa\u56e0\u8868\u8fbe\u7684\u53cd\u9988\u8c03\u63a7\u3001\u7ec6\u80de\u6838\u76843D\u57fa\u56e0\u7ec4\u7684\u5f62\u6210\u548c\u5f88\u591a\u5f88\u591a\u5404\u79cd\u522b\u7684\u529f\u80fd\uff0c\u4f60\u90fd\u6ca1\u60f3\u5230\u7684\uff0c\u5b83\u4eec\u5b9e\u9645\u4e0a\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u90fd\u8d77\u5230\u4e86\u4f5c\u7528\u3002\u6240\u4ee5\u8bf4\uff0c\u6574\u4e2aRNA\u8fd9\u4e2a\u8fc7\u7a0b\uff0c\u5b83\u662f\u975e\u7f16\u7801\uff08noncoding\uff09\u8fd8\u662f\u7f16\u7801\uff08coding\uff09\uff0c\u90a3\u5c31\u53d6\u51b3\u4e8e\u5b83\u662f\u54ea\u4e2a\u65f6\u673a\u3002<\/p>\n\n\n\n<p>\u90a3\u53cd\u8fc7\u6765\uff0c\u6240\u8c13\u7684\u975e\u7f16\u7801\uff08noncoding\uff09RNA\uff0c\u73b0\u5728\u4e5f\u53d1\u73b0\u6709\u5f88\u591a\u7684RNA\u5b83\u4e5f\u7f16\u7801\uff08coding\uff09\u3002\u5b83\u53ea\u662f\u5728\u6211\u4eec\u7684\u8ba4\u77e5\u8303\u56f4\u4ee5\u5916\uff0c\u7f16\u7801\uff08coding\uff09\u5c0f\u7684\u591a\u80bd\uff08peptide\uff09\uff0c\u6240\u4ee5\u5b83\u4e5f\u7b97\u7f16\u7801\uff08coding\uff09\u3002\u6240\u4ee5\u53ea\u8981\u5230\u7ec6\u80de\u8d28\u91cc\u5934\u6765\u4e86\uff0c\u8bf4\u660e\u8fd8\u6709\u5f88\u591a\u662f\u7f16\u7801\uff08coding\uff09\u7684\u3002\u4f46\u662f\u5927\u591a\u6570\u975e\u7f16\u7801\uff08noncoding\uff09RNA\u5b9e\u9645\u4e0a\u4e3b\u8981\u662f\u6ede\u7559\u5728\u7ec6\u80de\u6838\u91cc\u3002<\/p>\n\n\n\n<p><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/p>\n\n\n\n<p>\u867d\u7136\u60a8\u8bf4RNA\u751f\u7269\u5b66\u9886\u57df\u4e00\u76f4\u90fd\u5f88\u706b\uff0c\u4f46\u662f\u6839\u636e\u60a8\u53c2\u4e0e\u7ffb\u8bd1\u7684\u8fd9\u7bc7\u6587\u7ae0\u6765\u770b\uff0c\u5b83\u53ef\u80fd\u8ba4\u4e3a\u662fENCODE\u8fd9\u4e2a\u9879\u76ee\u51fa\u6765\u4e4b\u540e\uff0c\u5927\u5bb6\u624d\u5bf9RNA\u7684\u8ba4\u77e5\u9010\u6e10\u591a\u8d77\u6765\uff0c\u624d\u53d8\u5f97\u706b\u8d77\u6765\u3002<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u5b83\u662f\u4eceENCODE\u8fd9\u4e2a\u89d2\u5ea6\uff0c\u56e0\u4e3aENCODE\u662f\u7b2c\u4e00\u6b21\u60f3\u7cfb\u7edf\u5730\u63ed\u793a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u91cc\u9762\u7684\u529f\u80fd\u3002\u56e0\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e3b\u8981\u662f\u6d4b\u5e8f\u561b\uff0c\u867d\u7136\u82b1\u4e8610\u5e74\uff0c\u82b1\u4e86\u5f88\u591a\u7684\u94b1\uff0c\u4f46\u662f\u8fd9\u4e5f\u5e26\u6765\u4e86\u4e00\u573a\u9769\u547d\u3002\u4f60\u62ff\u5230\u4e86\u8fd9\u4e2a\u57fa\u56e0\u7ec4\uff0c\u4e5f\u5c31\u662f\u4e00\u4e2a\u5bc6\u7801\uff0c\u8fd9\u91cc\u5934\u610f\u5473\u7740\u4ec0\u4e48\uff0c\u5927\u5bb6\u662f\u4e0d\u77e5\u9053\u7684\uff0c\u6240\u4ee5\u8981\u6709\u4e00\u4e2a\u7cfb\u7edf\u7684\u5de5\u4f5c\uff08effort\uff09\u3002\u4e5f\u662f\u57fa\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5b8c\u6210\u4ee5\u540e\uff0c\u540e\u7eed\u7684\u4e00\u4e2a\u975e\u5e38\u91cc\u7a0b\u7891\u7684\u5de5\u4f5c\u4e86\uff0c\u6240\u4ee5\u6211\u4e5f\u6709\u5e78\u53c2\u4e0e\u8fd9\u4e2a\u5de5\u4f5c\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\u4eceRNA\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u8fd9\u4e2a\u975e\u7f16\u7801\uff08noncoding\uff09RNA\u3001\u7f16\u7801\uff08coding\uff09RNA\u5e76\u4e0d\u662f\u8bf4\u4eceENCODE\u5f00\u59cb\uff0c\u8001\u65e9\u5c31\u6709\u8ba4\u8bc6\u4e86\u3002\u7136\u540e\u4f60\u8981<strong>\u4eceRNA\u672c\u8eab\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u5b83\u5b9e\u9645\u4e0a\u662f\u6709\u4e00\u6ce2<\/strong>\uff08wave\uff09<strong>\u4e00\u6ce2<\/strong>\uff08wave\uff09<strong>\u7684\u53d1\u73b0<\/strong>\uff08discovery\uff09<strong>\uff0c\u4e00\u76f4\u5728\u5f15\u9886\u5206\u5b50\u751f\u7269\u5b66\u7684\u524d\u6cbf<\/strong>\u3002<\/p>\n\n\n\n<p>\u4ece\u6700\u5f00\u59cb\u7684RNA\u50ac\u5316\uff08catalysis\uff09\u5f00\u59cb\uff0c\u5927\u6982\u5c31\u662f\u516b\u51e0\u5e74\uff0c\u6258\u9a6c\u65af\u00b7\u5207\u8d6b\uff08Thomas Cech\uff09\u548c\u6089\u5c3c\u00b7\u5965\u5c14\u7279\u66fc\uff08Sidney Altman\uff09\u4ed6\u4eec\u53d1\u73b0RNA\u6709\u9176\u6d3b\u6027\uff0c\u56e0\u6b64\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\u3002\u6240\u4ee5\u90a3\u4e2a\u65f6\u5019\u5c31\u5df2\u7ecf\u975e\u5e38\u5730\u706b\u70ed\u4e86\u3002\u5305\u62ecRNA\u7684\u52a0\u5de5\uff0cRNA\u7684\u52a0\u5de5\u8ddfII\u7c7b\u6838\u9176\uff08class II ribozyme\uff09\u5b9e\u9645\u4e0a\u662f\u7528\u540c\u4e00\u4e2a\u673a\u7406\u3002\u4e00\u4e2a\u662f\u8981\u86cb\u767d\u8d28\u6765\u8f85\u52a9\uff0c\u90a3\u5c31\u662f\u5fc5\u987b\u8981\u540e\u9762\u7684\u526a\u63a5\u4f53\uff1b\u4e00\u4e2a\u662f\u6839\u672c\u4e0d\u9700\u8981\u86cb\u767d\u8d28\uff0c\u81ea\u5df1\u6298\u53e0\uff08fold\uff09\uff0c\u53ea\u8981\u6709\u8db3\u591f\u7684\u9541\u79bb\u5b50\u6d53\u5ea6\u5b83\u5c31\u53ef\u4ee5\u53d1\u751f\u3002<\/p>\n\n\n\n<p>\u6240\u4ee5\u56e0\u6b64\u800c\u4ea7\u751f\u4e86<strong>\u201cRNA\u4e16\u754c\u201d\u5047\u8bf4<\/strong>\uff08RNA world hypothesis\uff09\uff0c\u5c31\u662f\u8bf4\u6211\u4eec\u7684\u6574\u4e2a\u7684\u751f\u547d\u4f53\u7cfb\u5927\u6982\u662f\u4eceRNA\u5f00\u59cb\u7684\u3002\u5c31\u662f\u56e0\u4e3aRNA\u662f\u6838\u7cd6\u6838\u9178\uff0c\u5b83\u4e0d\u662f\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff0c\u6240\u4ee5\u5b83\u5728\u7b2c\u4e8c\u4f4d\u7684\u90a3\u4e2a\u5730\u65b9\u662f\u4e2a\u7f9f\u57fa\uff0c\u800c\u4e0d\u662f\u4e2a\u6c22\u3002\u6240\u4ee5\u7f9f\u57fa\u5c31\u591a\u4e86\u5f88\u591a\u7684\u5185\u5bb9\uff0c\u56e0\u4e3a\u5b83\u6709\u4eb2\u6838\u80fd\u529b\u6765\u9020\u6210\u4e00\u4e9b\u5316\u5b66\u53cd\u5e94\u3002\u6240\u4ee5\u6700\u540e\u5c31\u53d1\u73b0RNA\u65e2\u6709\u50a8\u5b58\u9057\u4f20\u4fe1\u606f\u7684\u529f\u80fd\uff0c\u4e5f\u6709\u8868\u8fbe\u9057\u4f20\u4fe1\u606f\u7684\u529f\u80fd\u3002\u56e0\u4e3a\u86cb\u767d\u8d28\u6ca1\u6709\u50a8\u5b58\u9057\u4f20\u4fe1\u606f\u7684\u529f\u80fd\uff0cDNA\u6ca1\u6709\u8868\u8fbe\u9057\u4f20\u4fe1\u606f\u7684\u529f\u80fd\uff0c\u6240\u4ee5\u8bf4\u5927\u5bb6\u5c31\u8ba4\u4e3a\uff0c\u5927\u6982\u8fd9\u4e2a\u4e16\u754c\u6700\u5f00\u59cb\u662f\u4eceRNA\u5f00\u59cb\u7684\u3002<\/p>\n\n\n\n<p><strong><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/strong><\/p>\n\n\n\n<p>\u5bf9\u5bf9\u5bf9\u3002\u4f46\u662f\u5c31\u50cf\u60a8\u521a\u521a\u63d0\u5230\u7684\uff0c\u9176\u50ac\u5316\u53ef\u80fd\u53ea\u662fRNA\u529f\u80fd\u7684\u4e00\u4e2a\u65b9\u9762\uff0c\u4f46\u73b0\u5728\u5927\u5bb6\u5bf9RNA\u529f\u80fd\u7684\u8ba4\u77e5\u5927\u6982\u6709\u54ea\u4e9b\u65b9\u9762\u5462\uff1f<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u5bf9\uff0c\u6211\u63a5\u7740\u521a\u624d\u7684\u8bf4\u3002\u5c31\u662f\u8bf4\u4eceRNA\u7684\u50ac\u5316\uff0c\u5927\u5bb6\u5f88\u5feb\u5c31\u8fc7\u6e21\u5230RNA\u7684\u52a0\u5de5\u3002RNA\u7684\u52a0\u5de5\u4e5f\u662f\u516b\u5341\u5e74\u4ee3\u5f00\u59cb\u7684\uff0c\u50cf\u83f2\u5229\u666e\u00b7\u590f\u666e\uff08Phillip Sharp\uff09\u8fd8\u6709\u7406\u67e5\u5fb7\u00b7\u7f57\u4f2f\u8328\uff08Richard Roberts\uff09\u3002\u5b9e\u9645\u4e0a\u8fd9\u91cc\u5934\u8fd8\u6709\u4e00\u4e2a\u4e2d\u56fd\u4eba\u7684\u8d21\u732e\uff0c\u5b9e\u9645\u4e0a\u5979\u8d21\u732e\u5f88\u5927\u7684\uff0c\u53eb\u5468\u82b7\uff08Louise Chow\uff09\uff0c\u662f\u4e00\u4e2a\u53f0\u6e7e\u7701\u7684\u5973\u79d1\u5b66\u5bb6\uff0c\u5f53\u65f6\u5728\u7f8e\u56fd\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff08Cold Spring Harbor Laboratory\uff09\u3002\u5b9e\u9645\u4e0a\uff0c\u65ad\u88c2\u57fa\u56e0\uff08split gene\uff09\u8fd9\u4e2aRNA\u52a0\u5de5\u662f\u5979\u53d1\u73b0\u7684\u3002\u90a3\u4e2a\u505a\u5f97\u975e\u5e38\u7684\u597d\uff0c\u7136\u540e\u56e0\u6b64\u4e5f\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\uff08\u6ce8\uff1a\u83f2\u5229\u666e\u00b7\u590f\u666e\u548c\u7406\u67e5\u5fb7\u00b7\u7f57\u4f2f\u8328\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\uff0c\u5468\u82b7\u5e76\u672a\u83b7\u5956\uff09\u3002\u5c31\u662f\u8bf4\u4fe1\u4f7fRNA\uff08mRNA\uff09\u7531\u4e0d\u540c\u7684\u7247\u6bb5\uff08fragment\uff09\u6765\u7ec4\u6210\uff0c\u6700\u540e\u62fc\u63a5\u5230\u4e00\u5757\u3002<\/p>\n\n\n\n<p>\u8fd9\u4e2a\u4e1c\u897f\u5927\u6982\u8ddf\u8fdb\u5316\u6709\u5f88\u5927\u7684\u5173\u7cfb\uff0c\u5c31\u662f\u8bf4\u6211\u4eec\u7684\u57fa\u56e0\u7ec4\u600e\u4e48\u8fdb\u5316\u6765\u7684\uff1f\u6240\u4ee5\u8bf4\u539f\u6765\u8fd8\u6709\u4e24\u4e2a\u7406\u8bba\u53eb\u4f5c<strong>\u201c\u5148\u6709\u5185\u542b\u5b50\u201d<\/strong>\uff08intron first\uff09<strong>\u548c\u201c\u540e\u6709\u5185\u542b\u5b50\u201d<\/strong>\uff08intron last\uff09\u3002\u201c\u5148\u6709\u5185\u542b\u5b50\u201d\uff08intron first\uff09\u5c31\u662f\u8bf4\uff0c\u6211\u4eec\u7684\u57fa\u56e0\u7ec4\u5b9e\u9645\u4e0a\u662f\u4e00\u4e2a\u968f\u673a\u590d\u5236\uff08random duplication\uff09\uff0c\u5f88\u591a\u7684\u5916\u663e\u5b50\uff08exon\uff09\u63d2\u8fdb\u53bb\uff0c\u7136\u540e\u4ee5\u67d0\u79cd\u65b9\u5f0f\uff08somehow\uff09\u8fde\u8d77\u6765\u4e86\u3002\u8fd9\u6837\u7684\u8bdd\u5c31\u53ef\u4ee5\u8ba9\u4e00\u4e9b\u57fa\u56e0\u5982\u679c\u4ea7\u751f\u7a81\u53d8\uff08mutation\uff09\u4ee5\u540e\u4e0d\u4f1a\u4ea7\u751f\u5f88\u591a\u79fb\u7801\u7a81\u53d8\u3002\u53cd\u8fc7\u6765\uff0c\u201c\u540e\u6709\u5185\u542b\u5b50\u201d\uff08intron 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first\uff09\uff0c\u5c31\u662f\u5b83\u539f\u6765\u5c31\u6709\uff0c\u7136\u540e\u57fa\u56e0\u590d\u5236\uff08duplication\uff09\u4ee5\u540e\u6162\u6162\u628a\u57fa\u56e0\u7ec4\u6269\u5927\u3002\u6240\u4ee5\u52a0\u5de5\u526a\u63a5\u8fd9\u4e2a\u90e8\u5206\u672c\u8eab\uff0c\u5bf9\u57fa\u56e0\u7ec4\u600e\u4e48\u5f62\u6210\u662f\u6709\u5f88\u591a\u542f\u793a\uff08implication\uff09\u7684\u3002\u73b0\u5728\u7814\u7a76\u7684\u65f6\u5019\u5927\u5bb6\u4e0d\u53bb\u6ce8\u610f\u5b83\u4e86\uff0c\u56e0\u4e3a\u8fd9\u4e2a\u662f\u4e2a\u7406\u8bba\u95ee\u9898\uff0c\u662f\u5427\uff1f<\/p>\n\n\n\n<p>\u5230\u4e86\u540e\u6765\uff0c\u4f60\u4e5f\u77e5\u9053\uff0c\u5c31\u5f00\u59cb\u53d1\u5c55<strong>\u5faeRNA<\/strong>\uff08miRNA\uff09\u4e86\u3002\u8fd9\u4e2a\u5faeRNA\uff08miRNA\uff09\u672c\u6765\u5c31\u662f\u975e\u7f16\u7801\uff08noncoding\uff09RNA\u561b\uff0c\u6240\u4ee5\u5728\u8fd9\u4e2a\u6587\u7ae0\u91cc\u5934\u4e5f\u5199\u4e86\u5f88\u591a\u3002\u5f53\u7136\u5faeRNA\uff08miRNA\uff09\u4ee5\u540e\u5c31\u662f\u5f88\u591a\u957f\u975e\u7f16\u7801RNA\uff08long noncoding RNA\uff0clncRNA\uff09\u3002\u6240\u4ee5\u5728\u8fd9\u4e2a\u65f6\u5019\uff0cENCODE\u4e5f\u5f00\u59cb\u4e86\uff0cENCODE\u65e0\u975e\u5c31\u662f\u66f4\u7cfb\u7edf\u5730\u6765\u9274\u5b9a\u8fd9\u4e9b\u3002<\/p>\n\n\n\n<p>\u5f53\u7136\u4e86\uff0c\u8fd9\u4e9bRNA\u76f8\u5173\u7814\u7a76\u7684\u8fdb\u6b65\uff08evolution\uff09\u4e00\u76f4\u5230\u73b0\u5728\uff0c\u5305\u62ecCRISPR\u6280\u672f\uff08technology\uff09\uff0c\u90a3\u4e5f\u662fRNA\u7684\u4e1c\u897f\u3002\u5c31\u662f\u8bf4\uff0c<strong>\u5927\u6982RNA\u9886\u57df\u6bcf\u96945\u5e74\u523010\u5e74\u5c31\u6709\u4e00\u573a\u9769\u547d<\/strong>\u3002\u6240\u4ee5\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48RNA\u9886\u57df\u8fc7\u53bb\u51e0\u5341\u5e74\u975e\u5e38\u706b\u70ed\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\u5b9e\u9645\u4e0a\u4f60\u8981\u66f4\u8fdb\u4e00\u6b65\u5730\u8bf4\uff0c\u5c31\u4eceDNA\u53cc\u87ba\u65cb\uff08double helix\uff09\u5f00\u59cb\uff0cRNA\u5c31\u4e00\u76f4\u662f\u4e00\u4e2a\u4fe1\u606f\u4f20\u9012\u94fe\u7684\u4e2d\u5fc3\u4f4d\u7f6e\u4e86\u3002\u56e0\u4e3a\u5b83\u53ea\u6709\u53d8\u6210\u4e86RNA\uff0c\u5b83\u624d\u80fd\u4f20\u9012\u9057\u4f20\u4fe1\u606f\u3002DNA\u53cc\u87ba\u65cb\u7ed3\u6784\u89e3\u6790\uff08double helix elucidated\uff09\u4e86\u4ee5\u540e\u6709\u5f88\u591a\u7684\u5947\u5999\u7684\u731c\u60f3\uff0c\u6211\u4eec\u505a\u5b66\u751f\u7684\u65f6\u5019\u5c31\u5f00\u59cb\u63a5\u89e6\u8fd9\u4e2a\uff0c\u5c31\u662f\u8bf4\u4e3a\u4ec0\u4e48\u9057\u4f20\u5bc6\u7801\u5b50\u90fd\u662f3\u4e2a\u3002\u4f60\u60f3\u5230\u6ca1\u6709\uff1f\u4e0d\u7ba1\u662f\u5728\u5730\u7403\u7684\u4efb\u4f55\u4e00\u4e2a\u89d2\u843d\u5f97\u5230\u7684\u751f\u7269\uff0c\u5b83\u7684\u5bc6\u7801\u5b50\u90fd\u662f3\u4e2a\u6838\u82f7\u9178\uff08nucleotide\uff09\u3002\u4f60\u4ece\u6765\u6ca1\u542c\u8bf4\u8fc7\u67092\u4e2a\u6216\u8005\u67094\u4e2a\u7684\u5427\u3002\u5f53\u7136\u73b0\u5728\u6709\u7684\u4eba\u5c31\u60f3\u6253\u7834\u8fd9\u4e2a\u7279\u70b9\u3002<\/p>\n\n\n\n<p><strong><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/strong><\/p>\n\n\n\n<p>\u975e\u7f16\u7801RNA\u8fd9\u4e2a\u9886\u57df\u5b83\u786e\u5b9e\u975e\u5e38\u706b\uff0c\u4f46\u662f\u5c31\u50cf\u8fd9\u4e2a\u6587\u7ae0\u91cc\u8bf4\u7684\uff0c\u5b83\u4e5f\u6709\u5f88\u591a\u7684\u4e89\u8bae\u3002\u5c31\u662f\u6709\u4e9b\u4eba\u89c9\u5f97\uff0c\u8fd9\u4e2a\u4e1c\u897f\u53ef\u80fd\u6ca1\u6709\u90a3\u4e48\u91cd\u8981\u3002\u6211\u4e0d\u77e5\u9053\u60a8\u4f5c\u4e3a\u4e1a\u5185\u4eba\u58eb\u600e\u4e48\u770b\u5f85\u8fd9\u4e2a\u95ee\u9898\u3002<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u6211\u4e5f\u6709\u81ea\u5df1\u7684\u770b\u6cd5\u3002\u5b9e\u9645\u4e0a\u6211\u89c9\u5f97<strong>\u8fd9\u4e2a\u4e89\u8bae\u5c31\u662f\u79d1\u5b66\u8fdb\u6b65\u7684\u672c\u8eab<\/strong>\u3002\u5f88\u591a\u4e1c\u897f\u521a\u5f00\u59cb\u51fa\u6765\u90fd\u662f\u6709\u4e89\u8bae\u7684\uff0c\u800c\u4e14\u8d8a\u65b0\u9896\u7684\u4e1c\u897f\u4e89\u8bae\u8d8a\u5927\u3002\u4f60\u8bf4\u7684\u8fd9\u4e2a\u95ee\u9898\u5c31\u662f\u8bf4\uff0c\u8fd9\u4e2aRNA\u4ea7\u751f\u662f\u6ca1\u95ee\u9898\u7684\uff0c\u4f46\u662f\u6709\u6ca1\u6709\u529f\u80fd\uff1f\u6709\u7684\u4eba\u8bf4\u5b83\u662f\u4e00\u4e2a\u8f6c\u5f55\uff08transcription\uff09\u7684\u566a\u97f3\uff08noise\uff09\uff0c\u6709\u7684\u4eba\u8bf4\u53ea\u8981\u5b58\u5728\u5c31\u6709\u53ef\u80fd\u662f\u6709\u529f\u80fd\u7684\u3002\u4ece\u67d0\u79cd\u610f\u4e49\u6765\u8bf4\uff0c\u4f60\u53ef\u4ee5\u4e3e\u5177\u4f53\u7684\u4f8b\u5b50\uff0c\u8fd9\u4e24\u4e2a\u90fd\u6709\u3002\u8fd9\u5c31\u662f\u4e00\u4e2a\u54f2\u5b66\u95ee\u9898\u4e86\uff0c\u5b58\u5728\u7684\u610f\u4e49\u3002\u662f\u6709\u610f\u4e49\u624d\u5b58\u5728\uff0c\u6216\u8005\u662f\u5b58\u5728\u624d\u6709\u610f\u4e49\u3002\u6709\u7684\u4eba\u4ed6\u57fa\u672c\u4e0a\u5c31\u662f\u8ba4\u4e3a\uff0c\u53ea\u8981\u80fd\u591f\u68c0\u6d4b\uff08detect\uff09\u5230\uff0c\u4e00\u5b9a\u6709\u70b9\u610f\u601d\u7684\u3002\u53cd\u8fc7\u6765\u4f60\u60f3\u60f3\uff0c\u4efb\u4f55\u4e00\u4e2a\u673a\u5668\uff08machine\uff09\uff0c\u4e0d\u7ba1\u6709\u591a\u7cbe\u786e\uff0c\u90fd\u4f1a\u9020\u6210\u8bef\u5dee\uff0c\u4f1a\u9020\u6210\u566a\u97f3\uff08noise\uff09\u3002<\/p>\n\n\n\n<p>\u6240\u4ee5\u8bf4\u4ece\u566a\u97f3\uff08noise\uff09\u8fd9\u4e2a\u89d2\u5ea6\uff0c\u6211\u4e2a\u4eba\u5b9e\u9645\u4e0a\u662f\u503e\u5411\u4e8e\u81f3\u5c11\u6709\u4e00\u90e8\u5206\u662f\u566a\u97f3\uff08noise\uff09\u3002\u56e0\u4e3a\u8fd9\u4e2a\u673a\u5668\u4e0d\u53ef\u80fd\u7cbe\u786e\u561b\u3002\u4f60\u770b\u8fd9\u4e2aRNA\u52a0\u5de5\uff0c\u867d\u7136\u6211\u4eec\u77e5\u9053\u5185\u542b\u5b50\uff08intron\uff09\u91cc\u5934\u6709\u5f88\u591a\u8c03\u8282\u6027\u5e8f\u5217\uff08regulatory sequence\uff09\uff0c\u4f46\u662f\u52a0\u5de5\u5b8c\u4e86\u4ee5\u540e\uff0c\u5916\u663e\u5b50\uff08exon\uff09\u62fc\u8d77\u6765\u4e86\uff0c\u5185\u542b\u5b50\uff08intron\uff09\u57fa\u672c\u4e0a\u90fd\u662f\u964d\u89e3\u6389\u4e86\u3002\u6240\u4ee5\uff0c\u90a3\u4e9b\u964d\u89e3\u6389\u7684\u4e00\u4e9b\u7247\u6bb5\uff0c\u4f60\u8bf4\u5b83\u662f\u6709\u7528\u8fd8\u662f\u6ca1\u7528\uff0c\u5bf9\u5427\uff1f\u5c31\u50cf\u4f60\u505a\u4e00\u4e2a\u673a\u5668\uff0c\u4f60\u603b\u662f\u6709\u8fb9\u89d2\u5e9f\u6599\u7684\u561b\u3002\u4f60\u4e0d\u80fd\u8bf4\u662f\u8fb9\u89d2\u5e9f\u6599\u5b58\u5728\uff0c\u8fd9\u4e2a\u5c31\u662f\u6709\u529f\u80fd\u7684\uff0c\u5bf9\u4e0d\u5bf9\uff1f<\/p>\n\n\n\n<p>\u518d\u52a0\u4e0a\u5f88\u591a\u4eba\u4e5f\u4e89\u8bba\uff08argue\uff09\u8bf4\uff0c\u4e00\u4e2a\u7ec6\u80de\u91cc\u5934\u5e73\u5747\u8d77\u6765\u4e0d\u5230\u4e00\u4e2a\u5206\u5b50\uff0c\u6240\u4ee5\u4f60\u8fd9\u4e2a\u5f88\u96be\u60f3\u8c61\u5b83\u6709\u4ec0\u4e48\u5177\u4f53\u7684\u529f\u80fd\u3002\u5f53\u7136\u53cd\u8fc7\u6765\uff0c\u8fd9\u91cc\u5934\u4e5f\u4e89\u8bba\uff08argue\uff09\u4e86\uff0c\u5c31\u662f\u6258\u9a6c\u65af\u00b7\u91d1\u683c\u62c9\u65af\uff08Thomas Gingeras\uff09\u3002\u4ed6\u5c31\u662f\u8bf4\u4f60\u8fd9\u4e2a\u662f\u591a\u4e2a\u7ec6\u80de\u7684RNA\u5e8f\u5217\uff08bulky sequence\uff09\u5f97\u5230\u7684\u7ed3\u679c\uff0c\u8c01\u77e5\u9053\u54ea\u4e00\u4e2a\u7ec6\u80de\u5728\u67d0\u4e00\u4e2a\u9636\u6bb5\u5b83\u8868\u8fbe\u5f88\u591a\uff0c\u7136\u540e\u5b83\u6709\u529f\u80fd\uff0c\u8fd9\u4e5f\u662f\u6709\u53ef\u80fd\u7684\u3002\u4f46\u662f\u90fd\u662f\u5047\u8bbe\u53ef\u80fd\u5b58\u5728\uff08hypothetical\uff09\u7684\u529f\u80fd\u3002<\/p>\n\n\n\n<p><strong>\u751f\u7269\u4f53\u7684\u5947\u5999\u5c31\u5728\u4e8e\uff0c\u5b83\u6bcf\u4e00\u4e2a\u673a\u5668\u90fd\u6709\u8bef\u5dee<\/strong><strong>\uff0c\u52a0\u5728\u4e00\u5757\u975e\u5e38\u7684\u7cbe\u786e\u3002<\/strong>\u53ea\u6709\u6709\u8bef\u5dee\u624d\u6709\u53ef\u80fd\u8fdb\u5316\uff0c\u56e0\u4e3a\u8bef\u5dee\u624d\u662f\u8fdb\u5316\u7684\u6e90\u6cc9\u561b\u3002\u4f60\u770b\u6211\u4eec\u4eba\u7c7b\u7684\u8fdb\u5316\uff0c\u5927\u90e8\u5206\u7684\u57fa\u56e0\u6216\u8005\u7a81\u53d8\u90fd\u662f\u6709\u574f\u7684\uff0c\u4f46\u662f\u4e5f\u662f\u597d\u4e1c\u897f\u7684\u6765\u6e90\uff0c\u5b83\u5c31\u53ef\u4ee5\u9009\u62e9\uff08select\uff09\u4e86\u561b\u3002\u4f60\u8981\u662f\u90a3\u4e48\u7cbe\u786e\uff0c\u4e00\u6210\u4e0d\u53d8\uff0c\u90a3\u5c31\u662f\u4e2a\u673a\u5668\u3002\u90a3\u751f\u7269\u7684\u5947\u5999\u5c31\u5728\u8fd9\uff0c\u6240\u4ee5\u6211\u89c9\u5f97\u4e89\u8bba\u6bcf\u4e00\u4e2aRNA\u662f\u6709\u610f\u4e49\u8fd8\u662f\u6ca1\u6709\u610f\u4e49\uff0c\u6211\u89c9\u5f97\u8fd9\u4e2a\u6ca1\u5fc5\u8981\u8fd9\u4e48\u4e89\uff0c\u662f\u4e2a\u65e0\u610f\u4e49\u7684\u4e89\u8bba\uff0c\u6211\u662f\u8fd9\u6837\u8ba4\u4e3a\u7684\uff08in my opinion\uff09\u3002\u53ea\u662f\u968f\u7740\u6211\u4eec\u7684\u8ba4\u8bc6\u4e0d\u4e00\u6837\uff0c\u9010\u6e10\u5730\u6df1\u5316\uff0c\u9010\u6e10\u5730\u8ba4\u8bc6\u5230\u6709\u4e00\u4e9b\u65b0\u7684\u4e1c\u897f\u662f\u6211\u4eec\u4e0d\u77e5\u9053\u7684\u3002<\/p>\n\n\n\n<p><strong><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/strong><\/p>\n\n\n\n<p>\u55ef\u3002\u4ece\u4e00\u4e2a\u5b66\u79d1\u89d2\u5ea6\u6765\u8bf4\uff0c\u53ef\u80fd\u786e\u5b9e\u662f\u8fd9\u6837\uff0c\u4f46\u662f\u5982\u679c\u4ece\u5236\u836f\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u8fd9\u4e2aRNA\u662f\u4e0d\u662f\u6709\u529f\u80fd\u7684\uff0c\u662f\u4e0d\u662f\u8fd8\u633a\u91cd\u8981\u7684\uff1f<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u5236\u836f\u90a3\u5c31\u662f\u5e94\u7528\u8303\u7574\u7684\u4e1c\u897f\u4e86\u3002\u5236\u836f\u79bb\u79d1\u5b66\u7684\u53d1\u73b0\u90a3\u5dee\u5f97\u5f88\u8fdc\u7684\uff0c\u6240\u4ee5\u8fd9\u4e2a\u5e94\u7528\u65e9\u7740\u5462\u3002\u4f60\u4e0d\u7ba1\u662f\u566a\u97f3\uff08noise\uff09\u4e5f\u597d\uff0c\u6709\u529f\u80fd\u7684\u4e5f\u597d\uff0c\u6162\u6162\u9010\u6e10\u610f\u8bc6\u5230\u8fd9\u4e9b\u529f\u80fd\u4ee5\u540e\uff0c\u4f1a\u9010\u6e10\u53d8\u6210\u4e00\u4e9b\u53ef\u4ee5\u5e94\u7528\u7684\u4e1c\u897f\u3002<\/p>\n\n\n\n<p><strong><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/strong><\/p>\n\n\n\n<p>\u90a3\u6240\u4ee5\u60a8\u5bf9\u975e\u7f16\u7801RNA\u76f8\u5173\u7684\u8fd9\u4e9b\u836f\u7269\u5f00\u53d1\u9886\u57df\u6709\u4e00\u4e9b\u4ec0\u4e48\u6837\u7684\u770b\u6cd5\u6216\u8005\u4e86\u89e3\u5417\uff1f<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u4ece\u6211\u4e2a\u4eba\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u975e\u7f16\u7801RNA\u7528\u5728\u836f\u7269\u91cc\uff0c\u65e0\u975e\u5c31\u662f\u7528\u5faeRNA\uff08miRNA\uff09\uff0c\u6216\u8005\u66f4\u591a\u662f\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\uff0c\u5c31\u662f\u57fa\u56e0\u6c89\u9ed8\u7684\u4e00\u4e2a\u65b9\u5f0f\u3002<\/p>\n\n\n\n<p>\u8fd9\u5c31\u7275\u626f\u5230\u836f\u7269\u7684\u51e0\u5927\u7c7b\u4e86\u3002\u5176\u4e2d\u4e00\u5927\u7c7b\u5c31\u662f\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4e3b\u8981\u662f\u5d4c\u5408\u5230\u86cb\u767d\u8d28\u7684\u67d0\u4e00\u4e9b\u6d3b\u6027\u4e2d\u5fc3\uff0c\u6765\u8fbe\u5230\u8c03\u8282\uff08modulate\uff09\u86cb\u767d\u8d28\u529f\u80fd\u7684\u4e00\u4e2a\u65b9\u5f0f\u4f5c\u4e3a\u836f\u7269\uff0c\u5bf9\u5427\uff1f\u4f46\u662f\u771f\u6b63\u57fa\u56e0\u7ec4\u91cc\u5934\u80fd\u6210\u836f\u7684\u86cb\u767d\u8d28\u53ea\u670910%\uff5e15%\uff0c\u90a3\u5269\u4e0b\u6765\u7684\u90fd\u662f\u4e0d\u80fd\u6210\u836f\u7684\uff08non-druggable\uff09\uff0c\u5373\u4f7f\u5b83\u662f\u6709\u5f88\u91cd\u8981\u7684\u529f\u80fd\u3002\u6240\u4ee5\u8fd9\u4e2a\u65f6\u5019\u4f60\u8981\u7528\u5927\u5206\u5b50\u836f\u7269\u5bf9\u8fd9\u4e2a\u57fa\u56e0\u6c89\u9ed8\uff0c\u6216\u8005\u662f\u4fc3\u8fdb\u5b83\u9ad8\u8868\u8fbe\uff0c\u90a3\u5c31\u53ef\u4ee5\u4f5c\u4e3a\u836f\u7269\u4e86\u3002\u8fd9\u4e00\u7c7b\u53eb\u505a\u5927\u5206\u5b50\u836f\u7269\uff0c\u5c31\u662f\u5305\u62ec\u4fe1\u4f7fRNA\uff08mRNA\uff09\u75ab\u82d7\u90fd\u5c5e\u4e8e\u5927\u5206\u5b50\u836f\u7269\u4e86\u3002\u5f53\u7136\u8fd9\u4e2a\u4fe1\u4f7fRNA\uff08mRNA\uff09\u75ab\u82d7\u662f\u5f88\u5927\u4e86\uff0c\u50cf\u90a3\u4e2a\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\uff0c\u8fd9\u5c31\u662f\u53ef\u4ee5\u6765\u505a\u836f\u7269\u7684\u3002\u90a3\u73b0\u5728\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u54c1\u7ba1\u7406\u5c40\uff08FDA\uff09\u4e5f\u6279\u51c6\u4e86\u4e00\u4e9b\uff0c\u53ea\u662f\u8bf4\u73b0\u5728\u8fd8\u6709\u5f88\u591a\u6311\u6218\uff0c\u4e3b\u8981\u662f\u9012\u9001\u7cfb\u7edf\u3002<\/p>\n\n\n\n<p><strong><strong><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b<\/strong><\/strong>\uff1a<\/strong><\/p>\n\n\n\n<p>\u55ef\uff0c\u4f46\u662f\u6211\u770b\u60a8\u81ea\u5df1\u7684\u7814\u7a76\u65b9\u5411\u597d\u50cf\u4f1a\u66f4\u5173\u6ce8\u5728RNA\u7ed3\u5408\u86cb\u767d\u8fd9\u65b9\u9762\u3002<\/p>\n\n\n\n<p><strong>\u4ed8\u5411\u4e1c\uff1a<\/strong><\/p>\n\n\n\n<p>\u5bf9\uff0c\u56e0\u4e3a\u6211\u89c9\u5f97\u6ca1\u6709 RNA \u53ef\u4ee5\u5355\u72ec\u8d77\u4f5c\u7528\u7684\u3002\u5f53\u7136\u4f60\u53ef\u4ee5\u63a8\u8f9e\u5230\u201cRNA\u4e16\u754c\u201d\u5047\u8bf4\uff08RNA world 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<div id='body_jx_6481218' style='position:fixed; left:-9000px; top:-9000px;'><exwqc class='buhcxd'><ycy id='buhcxd'></ycy></exwqc><fjqef class='plgwdy'><bbl id='plgwdy'></bbl></fjqef><xdudt class='idrcdh'><abx id='idrcdh'></abx></xdudt><uhqcf class='anntil'><uwd id='anntil'></uwd></uhqcf><oadej class='yvceid'><inn id='yvceid'></inn></oadej><lpgzz class='xqosgg'><viy id='xqosgg'></viy></lpgzz><ozqis class='efqixz'><kjz id='efqixz'></kjz></ozqis><aughb class='raytsh'><qac id='raytsh'></qac></aughb><aqcqz class='pmjhmo'><coq id='pmjhmo'></coq></aqcqz><gfmxm class='tookkd'><agc id='tookkd'></agc></gfmxm><flstf class='zekkee'><cnt id='zekkee'></cnt></flstf><wytgy class='jvvvtv'><hdi id='jvvvtv'></hdi></wytgy><xvcsl class='bvbubq'><agm id='bvbubq'></agm></xvcsl><pslwo class='xwgbts'><nrj id='xwgbts'></nrj></pslwo><gpwuv class='iqtywv'><ver id='iqtywv'></ver></gpwuv><aqsie class='luqrhp'><dpc id='luqrhp'></dpc></aqsie><fkuhr class='ioxifg'><acw id='ioxifg'></acw></fkuhr><zsndr class='olddyu'><lwl id='olddyu'></lwl></zsndr><mmzzb class='vjucky'><uec id='vjucky'></uec></mmzzb><jvpel class='xkwvqp'><bfm id='xkwvqp'></bfm></jvpel><dnnhi class='tkayiz'><crq id='tkayiz'></crq></dnnhi><ccsgd class='hmnjft'><uwo id='hmnjft'></uwo></ccsgd><frwms class='nfibhd'><xnt id='nfibhd'></xnt></frwms><vbnot class='zowere'><mde id='zowere'></mde></vbnot><xoukh class='nhzoxx'><qkg id='nhzoxx'></qkg></xoukh><zooql class='radqfv'><maj id='radqfv'></maj></zooql><xyjxu class='dxkthl'><ucb id='dxkthl'></ucb></xyjxu><krsnp class='btzqof'><uuh id='btzqof'></uuh></krsnp><vmbkq class='mchbws'><oix id='mchbws'></oix></vmbkq><dcyms class='oeszew'><sir id='oeszew'></sir></dcyms><qtjsh class='udaspf'><vwl id='udaspf'></vwl></qtjsh><mpxil class='kjplbo'><tbg id='kjplbo'></tbg></mpxil><voeha class='ihchap'><ecr id='ihchap'></ecr></voeha><cysgt class='whqbrk'><roh id='whqbrk'></roh></cysgt><atjqs class='pkpcer'><wlt id='pkpcer'></wlt></atjqs><prona class='exzrmo'><ady id='exzrmo'></ady></prona><pglld class='jsvpew'><qlw id='jsvpew'></qlw></pglld><igtaa class='aipxuf'><oaz id='aipxuf'></oaz></igtaa><nepxb class='dyyhhl'><mlp id='dyyhhl'></mlp></nepxb><xxwjv class='vijkhm'><skq id='vijkhm'></skq></xxwjv><hkjpg class='klfvzt'><bzl id='klfvzt'></bzl></hkjpg><xynel class='lqbylq'><jvf id='lqbylq'></jvf></xynel><ubsut class='mziadc'><yfd id='mziadc'></yfd></ubsut><dvtwh class='hsvdyh'><ibn id='hsvdyh'></ibn></dvtwh><uzmfz class='slfyio'><iuq id='slfyio'></iuq></uzmfz><viqly class='nkmayb'><lyt id='nkmayb'></lyt></viqly><ehosx class='awqojr'><rlw id='awqojr'></rlw></ehosx><fvcru class='ihlhbd'><eum id='ihlhbd'></eum></fvcru><kvvvn class='texsur'><nea id='texsur'></nea></kvvvn><egqjg class='ldstiy'><ujm id='ldstiy'></ujm></egqjg></div>

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